Melanoma is the deadliest form of skin cancer. When the disease is caught early, it can be easily treated. But once the cancer spreads, the prognosis is bleak. BRAF is the most commonly mutated gene associated with melanoma, found in more than 50 percent of patients. In healthy patients a segment of the BRAF protein known as the P-loop closes over the protein’s active site, guarding it from activation. More than 90 percent of melanoma patients have a BRAF mutation that locks the P-loop in an open position, keeping BRAF in an active state. Experimental drugs were specifically designed to occupy the area of the open P-loop. Read the full article here: Taking Aim at Melanoma.

Project: Cover and article design, layout and photo edit. Infographic to present how experimental drugs guard from BRAF activation.
Client: The Scientist Magazine